Bilecik Şeyh Edebali Üniversitesi Kurumsal Akademik Arşivi
DSpace@Bilecik, Bilecik Şeyh Edebali Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
DSpace@Bilecik, üyelik gerektirmeyen herkese açık bir sistemdir. Üyelik ve veri girişi sadece BŞEÜ mensuplarına (Öğrenci, idari ve akademik personel) özeldir.
Güncel Gönderiler
Synthesis, Theoretical, in Silico and in Vitro Biological Evaluation Studies of New Thiosemicarbazones as Enzyme Inhibitors
(Wiley-V C H Verlag Gmbh, 2023) Erdogan, Musa; Cavus, M. Serdar; Muglu, Halit; Yakan, Hasan; Turkes, Cuneyt; Demir, Yeliz; Beydemir, Sukru
Eleven new thiosemicarbazone derivatives (1-11) were designed from nine different biologically and pharmacologically important isothiocyanate derivatives containing functional groups such as fluorine, chlorine, methoxy, methyl, and nitro at various positions of the phenyl ring, in addition to the benzyl unit in the molecular skeletal structure. First, their substituted-thiosemicarbazide derivatives were synthesized from the treatment of isothiocyanate with hydrazine to synthesize the designed compounds. Through a one-step easy synthesis and an eco-friendly process, the designed compounds were synthesized with yields of up to 95 % from the treatment of the thiosemicarbazides with aldehyde derivatives having methoxy and hydroxy groups. The structures of the synthesized molecules were elucidated with elemental analysis and FT-IR, H-1-NMR, and C-13-NMR spectroscopic methods. The electronic and spectroscopic properties of the compounds were determined by the DFT calculations performed at the B3LYP/6-311++G(2d,2p) level of theory, and the experimental findings were supported. The effects of some global reactivity parameters and nucleophilic-electrophilic attack abilities of the compounds on the enzyme inhibition properties were also investigated. They exhibited a highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (K-I values are in the range of 23.54 +/- 4.34 to 185.90 +/- 26.16 nM, 103.90 +/- 23.49 to 325.90 +/- 77.99 nM, and 86.15 +/- 18.58 to 287.70 +/- 43.09 nM for AChE, hCA I, and hCA II, respectively). Furthermore, molecular docking simulations were performed to explain each enzyme-ligand complex's interaction.
Design and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation
(Wiley-V C H Verlag Gmbh, 2024) Durgun, Mustafa; Akocak, Suleyman; Lolak, Nebih; Topal, Fevzi; Kocyigit, Umit Muhammet; Turkes, Cueneyt; Isik, Mesut
The present study focused on the synthesis and characterization of novel pyrazole carboxamide derivatives (SA1-12). The inhibitory effect of the compounds on cholinesterases (ChEs; AChE and BChE) and carbonic anhydrases (hCAs; hCA I and hCA II) isoenzymes were screened as in vitro. These series compounds have been identified as potential inhibitors with a KI values in the range of 10.69 +/- 1.27-70.87 +/- 8.11 nM for hCA I, 20.01 +/- 3.48-56.63 +/- 6.41 nM for hCA II, 6.60 +/- 0.62-14.15 +/- 1.09 nM for acetylcholinesterase (AChE) and 54.87 +/- 7.76-137.20 +/- 9.61 nM for butyrylcholinesterase (BChE). These compounds have a more effective inhibition effect when compared to the reference compounds. In addition, the potential binding positions of the compounds with high affinity for ChE and hCAs were demonstrated by in silico methods. The results of in silico and in vitro studies support each other. As a result of the present study, the compounds with high inhibitory activity for metabolic enzymes, such as ChE and hCA were designed. The compounds may be potential alternative agents used as selective ChE and hCA inhibitors in the treatment of Alzheimer ' s disease and glaucoma. image
Production and Characterization of Electrodeposited Cadmium Sulfide Semiconductor Films with Different Boron Content
(Wiley-V C H Verlag Gmbh, 2024) Erdogan, Erman
In this study, Cadmium Sulfide (CdS) semiconductor films are electrodeposited on Indium Tin Oxide (ITO) substrates at 80 degrees C base temperature for different boric acid (H3BO3) ratios. The effect of boric acid on these films is investigated. For this, first of all, the structural change of the films is examined. Among the films obtained with different boric acid ratios, the optimum film is achieved with 0.06 m boric acid doped. From the basic absorption spectra (alpha hv) of the obtained CdS:B films, the variation of hv is drawn and it is determined that the CdS:B semiconductor films has a direct band transition. From the basic absorption spectra of the obtained CdS:B films, it is observed that the CdS:B semiconductor films has a direct band transition. In addition, the optical energy bandgap values obtained are in agreement with the values in the available literatures. The results of the structural, optical, and morphological properties of the films produced in this study indicate that among the selected additive ratios, 1% boric acid gives the best and optimum deposition condition. The thin films obtained are also found to be useful as absorber layers in photovoltaic solar cells. Cadmium Sulfide (CdS) is of great interest to researchers and is considered to be an important semiconductor material. The reason for the increasing interest in CdS is the development of new production techniques and the production of more functional CdS nanostructures and this allows the production of boron-doped CdS-based electronic and optoelectronic devices. image
One-Step Chronoamperometric Synthesized Nitrogen-Doped Graphene Oxide as a Novel Anode for Sodium-Ion Battery with an Enhanced Electrochemical Performance
(Wiley-V C H Verlag Gmbh, 2025) Almarzoge, Mohammedmustafa; Gencten, Metin; Ozsin, Gamzenur
Sodium-ion batteries (NIBs) have gained significant attention in recent years due to the global abundance and cost-effectiveness of sodium, making them a promising alternative to lithium-based batteries. In this study, nitrogen-doped graphene oxide powders (NGO) have been prepared in one step by using chronoamperometric method and then have been used as anode materials for NIBs. The NGO powder surface is covalently doped by C-N formation. The synthesized powder had few layers (similar to 3 layers) with nanocrystalline domain size (L alpha) similar to 46 nm, and the number of sp(2) carbon rings was calculated to be similar to 18. The initial discharge capacity recorded 199.8 mAh g(-1) at 0.1 C rate. Besides, the capacity retention for long-term cycling of 100 cycles at 2 C rate was 91.78 %. The deduced diffusion coefficient from galvanostatic intermittent titration technique (GITT) and electrochemical impedance spectroscopy (EIS) measurements for NGO as anode in NIBs is in the range of 10(-11)-10(-12) cm(2) s(-1). The electrochemical performance was attributed to the enhanced d-spacing of NGO up to 6.8 degrees A and formation large number of defects.
Exergy, Exergoeconomic and Enviroeconomic Evaluation of a Biomass Boiler-Steam Engine Micro-CHP System
(Wiley-V C H Verlag Gmbh, 2018) Acikkalp, Emin; Zeng, Thomas; Ortwein, Andreas; Burkhardt, Holger; Klenk, Werner
Biomass-based micro-combined heat-and-power (CHP) systems could play an important role in future renewable energy systems by providing net stability and balance electricity fluctuations from wind and solar systems by demand-driven and base load operations. A biomass boiler-steam engine micro-CHP system was investigated via exergy-based analysis methods to evaluate the optimization potential concerning exergy, environmental, and economic aspects. It was shown that the system has low exergy efficiency compared to systems from the literature and that the boiler is mainly affected by capital cost. Major improvements in terms of exergy efficiency as well as economics should therefore be focused on the boiler.
