Browsing by Author "Altıntop, Mehlika Dilek"
Now showing items 1-4 of 4
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Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
Belgin, Sever; Altıntop, Mehlika Dilek; Demir, Yeliz; Çiftçi Akalın, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Academic Press-Elsevier Science, 2020)Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ... -
An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives
Sever, Belgin; Altıntop, Mehlika Dilek; Demir, Yeliz; Pekdoğan, Muhammed; Akalın Çiftçi, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Elsevier, 2021)Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven ... -
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
Sever, Belgin; Türkeş, Cüneyt; Altıntop, Mehlika Dilek; Demir, Yeliz; Akalın Çiftçi, Gülşen; Beydemir, Şükrü (Wiley, 2021)New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on ... -
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Sever, Belgin; Türkeş, Cüneyt; Altıntop, Mehlika Dilek; Demir, Yeliz; Beydemir, Şükrü (Elsevier, 2020)Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase ...
