Browsing by Author "Demir, Yeliz"
Now showing items 1-13 of 13
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Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies
Türkeş, Cüneyt; Öztürk, Kesebir; Demir, Yeliz; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2021)Recently, as a drug target in cancer treatment, the superfamily of glutathione S-transferase (GSTs, EC 2.5.1.18) have been invited considerable interest by scientists. In particular, as they are overexpressed in many human ... -
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
Askın, Sercan; Tahtacı, Hakan; Türkeş, Cüneyt; Demir, Yeliz; Abdulilah, Ece; Akalın Çiftçi, Gülşen; Beydemir, Şükrü (Elsevier, 2021)Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ... -
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
Belgin, Sever; Altıntop, Mehlika Dilek; Demir, Yeliz; Çiftçi Akalın, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Academic Press-Elsevier Science, 2020)Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ... -
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α-glycosidase and molecular docking studies.
Demir, Yeliz; Taslimi, Parham; Koçyiğit, Ümit Muhammet; Akkuş, Musa; Özaslan, Muhammet Serhat; Duran , Hatice Esra; Budak, Yakup; Tüzün, Burak; Gürdere, Meliha Burcu; Ceylan, Mustafa; Taysi, Seyithan; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2020)Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. alpha-Glycosidase breaks down starch and disaccharides to glucose. Hence, ... -
An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives
Sever, Belgin; Altıntop, Mehlika Dilek; Demir, Yeliz; Pekdoğan, Muhammed; Akalın Çiftçi, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Elsevier, 2021)Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven ... -
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
Sever, Belgin; Dilek Altıntop, Mehlika; Demir, Yeliz; Yılmaz, Nalan; Akalın Çiftçi, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Elsevier, 2021)Aldose reductase (AR) acts as a multi-disease target for the design and development of therapeutic agents for the management of diabetic complications as well as non-diabetic diseases. In the search for potent AR inhibitors, ... -
Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2021)Glutathione S-transferases (EC 2.5.1.18, GSTs), consisting of at least seven subfamilies, such as alpha, kappa, mu, pi, theta, zeta, and omega, are the family of cytosolic proteins with many known functions and also are ... -
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors
Kalaycı, Muharrem; Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2020)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) ... -
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
Sever, Belgin; Türkeş, Cüneyt; Altıntop, Mehlika Dilek; Demir, Yeliz; Akalın Çiftçi, Gülşen; Beydemir, Şükrü (Wiley, 2021)New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on ... -
Purification of the phytase enzyme fromLactobacillus plantarum: The effect on pansy growth and macro-micro element content
Parlakova Karagöz, Fazilet; Demir, Yeliz; Şenol Kotan, Merve; Dursun, Atilla; Beydemir, Şükrü; Dikbaş, Neslihan (Wiley, 2021)In the present study, the phytase enzyme was purified fromLactobacillus plantarumwith a 3.08% recovery, 9.57-purification fold, and with a specific activity of 278.82 EU/mg protein. Then, the effects of the 5 EU and 10 EU ... -
Some calcium-channel blockers: kinetic andin silicostudies on paraoxonase-I
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Taylor & Francis, 2020)Many drugs, which are used in clinical treatments, show pharmacological effects on enzyme activity with an essential role in the pathogenesis of various diseases. Paraoxonase-I (PON1) is a member of the mammalian lactonase ... -
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors
Tokalı, Feyzi Sinan; Demir, Yeliz; Demircioğlu, İbrahim Hakkı; Türkeş, Cüneyt; Kalay, Erbay; Şendil, Kıvılcım; Beydemir, Şükrü (Wiley, 2021)A series of novel sulfonates containing quinazolin-4(3H)-one ring derivatives was designed to inhibit aldose reductase (ALR2, EC 1.1.1.21). Novel quinazolinone derivatives (1-21) were synthesized from the reaction of ... -
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Sever, Belgin; Türkeş, Cüneyt; Altıntop, Mehlika Dilek; Demir, Yeliz; Beydemir, Şükrü (Elsevier, 2020)Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase ...
