Rektörlüğe Bağlı Birimler
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Rektörlüğe Bağlı Birimler_Yayın Koleksiyonu [39]
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Yapay Sinir Ağları Kullanarak Bilgisayar Ağlarında Saldırı Tespit Sistemi ve Başarımlarının İncelenmesi
(Gaziosmanpaşa Üniversitesi, 2015)Her geçen gün önemi artan bilgi ve ağ üzerindeki bilgi sistemlerine yapılan saldırıların tespit edilmesinde kullanılan saldırı tespit sistemleri (STS) Yapay Sinir Ağları (YSA) kullanılarak ele alınmıştır. STS’lerin ... -
Integrated Microfluidic Chip Development for the Quantification of Antibiotic Permeability Rates through Bacteria Cell Wall
(2019)Microfluidic chips have gained a lot of interest of researchers due to their ease of fabrication, cost-effectiveness, durability, and portability and these are highly preferable to handle micro and nano particles because ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
(Wiley, 2020)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α-glycosidase and molecular docking studies.
(Wiley, 2020)Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. alpha-Glycosidase breaks down starch and disaccharides to glucose. Hence, ... -
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
(Academic Press - Elsevier Science, 2020)Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ... -
Some calcium-channel blockers: kinetic andin silicostudies on paraoxonase-I
(Taylor & Francis, 2020)Many drugs, which are used in clinical treatments, show pharmacological effects on enzyme activity with an essential role in the pathogenesis of various diseases. Paraoxonase-I (PON1) is a member of the mammalian lactonase ... -
Purification of the phytase enzyme fromLactobacillus plantarum: The effect on pansy growth and macro-micro element content
(Wiley, 2021)In the present study, the phytase enzyme was purified fromLactobacillus plantarumwith a 3.08% recovery, 9.57-purification fold, and with a specific activity of 278.82 EU/mg protein. Then, the effects of the 5 EU and 10 EU ... -
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors
(Wiley, 2020)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) ... -
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
(Elsevier, 2020)Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase ... -
Mannich reaction derived novel boron complexes with amine-bis(phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies
(Elsevier, 2020)The amine-bis(phenolate) ligands was prepared through a Mannich reaction utilizing two equivalents of 2,4-di-tert-butylphenol or 4-tert-butylphenol, two equivalents of formaldehyde and a single equivalent of 2-aminoethyl ... -
An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives
(Elsevier, 2021)Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven ... -
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
(Elsevier, 2021)Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ... -
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
(Elsevier, 2021)Aldose reductase (AR) acts as a multi-disease target for the design and development of therapeutic agents for the management of diabetic complications as well as non-diabetic diseases. In the search for potent AR inhibitors, ... -
Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies
(Wiley, 2021)Recently, as a drug target in cancer treatment, the superfamily of glutathione S-transferase (GSTs, EC 2.5.1.18) have been invited considerable interest by scientists. In particular, as they are overexpressed in many human ... -
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
(Wiley, 2021)New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on ... -
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors
(Wiley, 2021)A series of novel sulfonates containing quinazolin-4(3H)-one ring derivatives was designed to inhibit aldose reductase (ALR2, EC 1.1.1.21). Novel quinazolinone derivatives (1-21) were synthesized from the reaction of ... -
Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study
(Wiley, 2021)Glutathione S-transferases (EC 2.5.1.18, GSTs), consisting of at least seven subfamilies, such as alpha, kappa, mu, pi, theta, zeta, and omega, are the family of cytosolic proteins with many known functions and also are ... -
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes
(Wiley, 2022)Carbonic anhydrases (CAs, Enzyme Commission 4.2.1.1) convert carbon dioxide to bicarbonate in metabolism and use Zn2+ ions as a cofactor for their catalytic activity. The activators or inhibitors of CA-I and CA-II, which ... -
An Accelerated Method for Determining the Weights of Quadratic Image Filters
(IEEE, 2018)Quadratic filters are usually more successful than linear filters in dealing with nonlinear noise characteristics. However, determining the proper weights for the success of quadratic filters is not straightforward as ... -
The reactions of hexachlorocyclotriphosphazene with piperidine, N-(1-naphthyl)ethylenediamine and 2-(2-hydroxyethylamino)ethanol. Antimicrobial activities of iminodiethoxy-substituted cyclotriphosphazene derivatives
(Taylor & Francis, 2021)A series of cyclotriphosphazene derivatives (5–16) were synthesized from the reactions of hexachlorocyclotriphosphazene (1, N3P3Cl6) with piperidine (2), N-(1-naphthyl)ethylenediamine (3) and 2-(2-hydroxyethylamino)ethanol ...
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