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dc.contributor.authorKeskin, Şaban
dc.contributor.authorÇakır, Hilal Ebru
dc.contributor.authorŞirin, Yakup
dc.contributor.authorKeskin, Merve
dc.date.accessioned2019-09-11T06:44:09Z
dc.date.available2019-09-11T06:44:09Z
dc.date.issuedJAN 2019en_US
dc.identifier.citationKeskin, Ş., Şirin, Y., Çakir, H. E., & Keskin, M. (2019). An investigation of Humulus lupulus L.: Phenolic composition, antioxidant capacity and inhibition properties of clinically important enzymes. South African journal of botany, 120, 170-174.en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2018.04.017
dc.identifier.urihttps://hdl.handle.net/11552/362
dc.descriptionKeskin, Şaban (Bilecik, Author)en_US
dc.description.abstractHumulus lupulus L., known as hop, is used mostly in brewing industry. It is known that hops have some secondary metabolites having significant biological activities. As far as we know this is the first paper reporting urease, alpha-amylase and acetylcholinesterase inhibition activity of hop extracts. In this study, phenolic composition, antioxidant capacities, and some clinically important enzyme inhibition properties of the methanol extracts were investigated. Total polyphenolic content (TPC), ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity tests were used for antioxidant activity determinations. Inhibition activity of the extracts on three clinically important enzymes of urease, alpha-amylase and acetylcholinesterase was studied. Polyphenolic composition of the extracts was identified by using RP-HPLC-UV in the presence of fourteen phenolic standards. TPC was found 7.12 +/- 0.09 and 6.86 +/- 0.05 mg GAE/g in methanol extract of hop cone and leaf respectively. It was found that methanol extract of hop cones and leaves showed good urease (IC50 0.58 +/- 0.02 and 0.87 +/- 0.02 mg/mL), acetylcholinesterase (IC50 2.13 +/- 0.03 and 4.18 +/- 0.02 mg/mL) and alpha-amylase (IC50 3.92 +/- 0.02 and 6.05 +/- 0.03 mg/mL) inhibitory effect respectively. It can be concluded that methanol extract of H. lupulus may be an alternative for the treatment of peptic ulcer, Alzheimer's disease and diabetes mellitus. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.sajb.2018.04.017en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHumulus lupulus L.en_US
dc.subjectAntioxidant activityen_US
dc.subjectInhibitionen_US
dc.subjectUreaseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectalpha-Amylaseen_US
dc.subjectPeptic ulceren_US
dc.subjectAlzheimer's diseaseen_US
dc.titleAn investigation of Humulus lupulus L.: Phenolic composition, antioxidant capacity and inhibition properties of clinically important enzymesen_US
dc.typearticleen_US
dc.relation.journalSouth African Journal of Botanyen_US
dc.contributor.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.contributor.authorID0000-0002-0287-4268en_US
dc.identifier.volume120en_US
dc.identifier.startpage170en_US
dc.identifier.endpage174en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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