PubMed İndeksli Yayın Koleksiyonu
Recent Submissions
-
Clarification of Stevia rebaudiana Bertoni extract by Ca based silica microspheres
(Elsevier, 2019)Pre-treated Stevia rebaudiana Bertoni extract was clarified via using calcium (Ca) based silica (Si) microspheres. Both adsorption and chemical treatment were applied to extracts, and their effects on clarification were ... -
Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors
(Walter de Gruyter, 2020)Inhibition of aromatase enzymes is very important in the prevention of estrogen-related diseases and the regulation of estrogen levels. Aromatase enzyme is involved in the final stage of the biosynthesis of estrogen, in ... -
Monitoring of glyphosate-DNA interaction and synergistic genotoxic effect of glyphosate and 2,4-dichlorophenoxyacetic acid using an electrochemical biosensor
(Elsevier, 2021)Glyphosate (GLY) is a broad-spectrum herbicide used worldwide to control broadleaf sedge, and grass weeds to control non-specific vegetation. Although it was evaluated as non-toxic agent in 20th century, its carcinogenic ... -
Trunk control: The essence for upper limb functionality in patients with multiple sclerosis
(Elsevier Science, 2018)Background: Multiple sclerosis (MS) involves impaired trunk control, leading to impaired upper-limb functionality, dexterity, and independence. Deciding early on a comprehensive approach pointing of functional disturbances ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
(Wiley, 2020)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α-glycosidase and molecular docking studies.
(Wiley, 2020)Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. alpha-Glycosidase breaks down starch and disaccharides to glucose. Hence, ... -
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
(Academic Press - Elsevier Science, 2020)Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ... -
Some calcium-channel blockers: kinetic andin silicostudies on paraoxonase-I
(Taylor & Francis, 2020)Many drugs, which are used in clinical treatments, show pharmacological effects on enzyme activity with an essential role in the pathogenesis of various diseases. Paraoxonase-I (PON1) is a member of the mammalian lactonase ... -
Purification of the phytase enzyme fromLactobacillus plantarum: The effect on pansy growth and macro-micro element content
(Wiley, 2021)In the present study, the phytase enzyme was purified fromLactobacillus plantarumwith a 3.08% recovery, 9.57-purification fold, and with a specific activity of 278.82 EU/mg protein. Then, the effects of the 5 EU and 10 EU ... -
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors
(Wiley, 2020)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) ... -
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
(Elsevier, 2020)Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase ... -
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
(Elsevier, 2021)Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ... -
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
(Elsevier, 2021)Aldose reductase (AR) acts as a multi-disease target for the design and development of therapeutic agents for the management of diabetic complications as well as non-diabetic diseases. In the search for potent AR inhibitors, ... -
Learning Needs of Patients and Their Caregivers After Ambulatory Surgery
(Elsevier Science, 2020)Purpose: The purpose of this study was to determine the learning needs of ambulatory surgery patients and their caregivers. Design: The study was a cross-sectional and descriptive survey. Methods: The study was conducted ... -
VSI: Environment & Energy
(Elsevier Science, 2020)"VSI: Environment & Energy" isimli yayının özeti bulunmamaktadır. -
Silicon nitride ceramic for all-ceramic dental restorations
(Japanese Society Dental Materials Devices, 2020)Silicon nitride (Si3N4) is one of the promising ceramics for dental restoration due to providing significant benefits during the application. This study aimed to investigate the potential use of Si3N4 for all-ceramic ... -
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
(Wiley, 2021)New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on ... -
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors
(Wiley, 2021)A series of novel sulfonates containing quinazolin-4(3H)-one ring derivatives was designed to inhibit aldose reductase (ALR2, EC 1.1.1.21). Novel quinazolinone derivatives (1-21) were synthesized from the reaction of ... -
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes
(Wiley, 2022)Carbonic anhydrases (CAs, Enzyme Commission 4.2.1.1) convert carbon dioxide to bicarbonate in metabolism and use Zn2+ ions as a cofactor for their catalytic activity. The activators or inhibitors of CA-I and CA-II, which ... -
Rapid fabrication of teflon apertures by controlled high voltage pulses for formation of free standing planar lipid bilayer membrane
(Springer, 2021)Free standing artificial lipid bilayers are widely used in the study of biological pores. In these types of studies, the free standing planar lipid bilayer is formed over a micron-sized aperture consisting of either polymer ...
RSS 1.0
