Browsing by Author "Lolak, Nebih"
Now showing items 1-4 of 4
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Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Yapar, Gönül; Duran, Hatice Esra; Lolak, Nebih; Akocak, Süleyman; Türkeş, Cüneyt; Durgun, Mustafa; Işık, Mesut; Beydemir, Şükrü (Academic Press-Elsevier Science, 2021)Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to prevent diabetic complications. In the present study, ... -
Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors
Lolak, Nebih; Akoçak, Süleyman; Durgun, Mustafa; Duran, Hatice Esra; Necip, Adem; Türkeş, Cüneyt; Işık, Mesut; Beydemir, Şükrü (Springer, 2022)To discover alternative substances to compounds used to treat many diseases, especially treating Alzheimer’s disease (AD) and Parkinson’s disease targeting carbonic anhydrase (hCA) and acetylcholinesterase (AChE) enzymes, ... -
Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and alpha-glucosidase inhibitors
Türkeş, Cüneyt; Akocak, Süleyman; Işık, Mesut; Lolak, Nebih; Taslımı, Parham; Durgun, Mustafa; Gülçin, İlhami; Budak, Yakup; Beydemir, Şükrü (Taylor & Francis, 2022)The underlying cause of many metabolic diseases is abnormal changes in enzyme activity in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, ... -
Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as alpha-Glycosidase and Cholinesterase Inhibitors
Akocak, Süleyman; Taslımı, Parham; Lolak, Nebih; Işık, Mesut; Durgun, Mustafa; Budak, Yakup; Türkeş, Cüneyt; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2021)A series of six N-carbamimidoyl-4-(3-substituted phenylureido)benzenesulfonamide derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In vitro and in silico inhibitory effects of the novel ...
