Browsing by WoS Q Value "Early Access"
Now showing items 1-20 of 34
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Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
(Wiley, 2022)Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium-dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates, esters, and organophosphates. In the current study, we ... -
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
(Springer, 2022)The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity antiepileptic, anticancer, antiinfective, antiglaucoma, ... -
A data driven forecasting model for active offenders on electronic monitoring systems in Türkiye
(İstanbul Üniversitesi - Cerrahpaşa, 2023)The electronic monitoring of offenders is an increasingly popular technique in the criminal justice system. Worldwide, these systems are effectively utilized to monitor individuals on probation as they serve their sentence ... -
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo- pyridazinone moiety
(Elsevier, 2022)The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose reductase (ALR2), is a drug target for ... -
Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors
(Wiley, 2022)Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory ... -
A detailed thermodynamic analysis of CO2 hydrogenation to produce methane at low pressure
(Pergamon-Elsevier Science, 2023)Evaluation of CO2, which is harmful to the environment, as an alternative energy source in CH4 production was investigated from a thermodynamic point of view. The methanation of CO2 is exothermic, however it does not occur ... -
An electrochemical label-free DNA impedimetric sensor with AuNP-modified glass fiber/carbonaceous electrode for the detection of HIV-1 DNA
(Springer, 2020)In this study, a highly sensitive, electrochemical, and label-free DNA impedimetric sensor was developed using carbonized glass fiber-coal tar pitch (GF-CTP) electrodes supported with gold nanoparticles (AuNPs) for the ... -
Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif
(Wiley, 2023)New Schiff base‐bearing thiosemicarbazones (1–13) were obtained from 4‐hydroxy‐3, 5‐dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail. Density functional ... -
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
(Pergamon-Elsevier Science, 2023)A novel series of 1,2,3-triazole benzenesulfonamide substituted 1,3-dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was designed using a tail approach. The design method relies on the ... -
Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors
(Wiley, 2023)Aldose reductase (AR, ALR2; EC 1.1.1.21), an enzyme that converts glucose to fructose on the polyol pathway, is an important member of the Aldo-keto reductase superfamily. ALR2 is part of the rate-limiting step, which is ... -
Green synthesis, characterization, and biochemical properties of waste walnut (Juglans regia L.) inner shell-based silver nanoparticles
(Serbian Chemical Society, 2024)Sustainability is important for future ecology and the increase of waste in recent years negatively affects sustainability. The management of waste and using them in the technology field could be a solution for ... -
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes
(Wiley, 2022)Carbonic anhydrases (CAs, Enzyme Commission 4.2.1.1) convert carbon dioxide to bicarbonate in metabolism and use Zn2+ ions as a cofactor for their catalytic activity. The activators or inhibitors of CA-I and CA-II, which ... -
In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors
(Wiley, 2022)Polyol pathway enzymes, aldose reductase (EC 1.1.1.21; AR, ALR2), and sorbitol dehydrogenase (EC 1.1.1.14; SDH, SORD) have been widely investigated as the enzymes crucially involved in the pathogenesis of several chronic ... -
Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies
(Wiley, 2022)Paraoxonase 1 (PON1) can metabolize some compounds such as aromatic carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide drugs, some carbamate insecticide classes, nerve gases, and ... -
Modeling of Listeria monocytogenes survival and quality attributes of sliced mushroom (Agaricus bisporus) subjected to pulsed UV light
(Wiley-Blackwell, 2021)Pulsed ultraviolet (PUV) light technology holds the potential for surface decontamina-tion of foods. In this study, the survival of L. monocytogenes and some quality attri-butes (color, moisture, water activity, and ... -
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
(Taylor & Francis, 2022)Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and ... -
Molecular Docking Studies and the Effect of Fluorophenylthiourea Derivatives on Glutathione-Dependent Enzymes
(Wiley, 2023)Cancer is a serious problem affecting the health of all human societies. Chemotherapy refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades, researchers have studied about proteins ... -
N-substituted phthalazine sulfonamide derivatives as non-classical aldose reductase inhibitors
(Wiley, 2022)Aldose reductase (AR, AKR1B1; EC 1.1.1.21) is an aldo-keto reductase that has been widely investigated as an enzyme crucially involved in the pathogenesis of several chronic complications, including nephropathy, neuropathy, ... -
A new series of hydrazones as small-molecule aldose reductase inhibitors
(Wiley, 2023)In the search for small-molecule aldose reductase (AR) inhibitors, new tetrazole-hydrazone hybrids (1-15) were designed. An efficient procedure was employed for the synthesis of compounds 1-15. All hydrazones were subjected ... -
Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
(Wiley, 2023)Aldose reductase (AR) is a crucial enzyme of the polyol pathway through whichglucose is metabolized under conditions of hyperglycemia related to diabetes. Aseries of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ...
