Browsing by Author "Beydemir, Şükrü"
Now showing items 1-20 of 44
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Benzenesulfonamide derivatives as potent acetylcholinesterase, alpha-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies
Taslimi, Parham; Işık, Mesut; Türkan, Fikret; Durgun, Mustafa; Türkeş, Cüneyt; Gülçin, İlhami; Beydemir, Şükrü (Taylor & Francis, 2020)Sulfonamide derivatives exhibit a wide biological activity and can function as potential medical molecules in the development of a drug. Studies have reported that the compounds have an effect on many enzymes. In this ... -
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Yapar, Gönül; Duran, Hatice Esra; Lolak, Nebih; Akocak, Süleyman; Türkeş, Cüneyt; Durgun, Mustafa; Işık, Mesut; Beydemir, Şükrü (Academic Press-Elsevier Science, 2021)Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to prevent diabetic complications. In the present study, ... -
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
Korkmaz, Işıl Nihan; Türkeş, Cüneyt; Demir, Yeliz; Öztekin, Aykut; Özdemir, Hasan; Beydemir, Şükrü (Wiley, 2022)Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium-dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates, esters, and organophosphates. In the current study, we ... -
Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies
Türkeş, Cüneyt; Öztürk, Kesebir; Demir, Yeliz; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2021)Recently, as a drug target in cancer treatment, the superfamily of glutathione S-transferase (GSTs, EC 2.5.1.18) have been invited considerable interest by scientists. In particular, as they are overexpressed in many human ... -
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
Güleç, Özcan; Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Yeni, Yeşim; Hacımüftüoğlu, Ahmet; Ereminsoy, Ergün; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Springer, 2022)The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity antiepileptic, anticancer, antiinfective, antiglaucoma, ... -
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo- pyridazinone moiety
Beydemir, Şükrü; Akdağ, Mevlüt; Özçelik, Azime Berna; Demir, Yeliz (Elsevier, 2022)The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose reductase (ALR2), is a drug target for ... -
Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors
Osmaniye, Derya; Türkeş, Cüneyt; Demir, Yeliz; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Beydemir, Şükrü (Wiley, 2022)Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory ... -
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
Aşkın, Sercan; Tahtacı, Hakan; Türkeş, Cüneyt; Demir, Yeliz; Ece, Abdulilah; Çiftçi, Gülşen Akalın; Beydemir, Şükrü (Academic Press-Elsevier Science, 2021)Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ... -
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
Belgin, Sever; Altıntop, Mehlika Dilek; Demir, Yeliz; Çiftçi Akalın, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Academic Press-Elsevier Science, 2020)Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ... -
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α-glycosidase and molecular docking studies.
Demir, Yeliz; Taslimi, Parham; Koçyiğit, Ümit Muhammet; Akkuş, Musa; Özaslan, Muhammet Serhat; Duran , Hatice Esra; Budak, Yakup; Tüzün, Burak; Gürdere, Meliha Burcu; Ceylan, Mustafa; Taysi, Seyithan; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2020)Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. alpha-Glycosidase breaks down starch and disaccharides to glucose. Hence, ... -
Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif
Demir, Yeliz; Türkeş, Cüneyt; Çavuş, Muhammet Serdar; Erdoğan, Musa; Muğlu, Halit; Yakan, Hasan; Beydemir, Şükrü (Wiley, 2023)New Schiff base‐bearing thiosemicarbazones (1–13) were obtained from 4‐hydroxy‐3, 5‐dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail. Density functional ... -
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
Kakakhan, Chnar; Türkeş, Cüneyt; Güleç, Özcan; Demir, Yeliz; Arslan, Mustafa; Özkemahlı, Gizem; Beydemir, Şükrü (Pergamon-Elsevier Science, 2023)A novel series of 1,2,3-triazole benzenesulfonamide substituted 1,3-dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was designed using a tail approach. The design method relies on the ... -
Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors
Türkeş, Cüneyt; Demir, Yeliz; Biçer, Abdullah; Cin, Günseli Turgut; Gültekin, Mehmet Serdar; Beydemir, Şükrü (Wiley, 2023)Aldose reductase (AR, ALR2; EC 1.1.1.21), an enzyme that converts glucose to fructose on the polyol pathway, is an important member of the Aldo-keto reductase superfamily. ALR2 is part of the rate-limiting step, which is ... -
An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives
Sever, Belgin; Altıntop, Mehlika Dilek; Demir, Yeliz; Pekdoğan, Muhammed; Akalın Çiftçi, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Elsevier, 2021)Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven ... -
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
Sever, Belgin; Dilek Altıntop, Mehlika; Demir, Yeliz; Yılmaz, Nalan; Akalın Çiftçi, Gülşen; Beydemir, Şükrü; Özdemir, Ahmet (Elsevier, 2021)Aldose reductase (AR) acts as a multi-disease target for the design and development of therapeutic agents for the management of diabetic complications as well as non-diabetic diseases. In the search for potent AR inhibitors, ... -
The impact of some phenolic compounds on serum acetylcholinesterase: kinetic analysis of an enzyme/inhibitor interaction and molecular docking study
Işık, Mesut; Beydemir, Şükrü (Taylor & Francis, 2020)In the treatment of Alzheimer’s disease (AD), it is important to develop alternative cholinesterase inhibitors with antioxidant properties that will reduce acetylcholine deficiency and free radical formation. The aim of ... -
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes
Güller, Uğur; Beydemir, Şükrü; Küfrevioğlu, Ömer İrfan (Wiley, 2022)Carbonic anhydrases (CAs, Enzyme Commission 4.2.1.1) convert carbon dioxide to bicarbonate in metabolism and use Zn2+ ions as a cofactor for their catalytic activity. The activators or inhibitors of CA-I and CA-II, which ... -
In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2022)Polyol pathway enzymes, aldose reductase (EC 1.1.1.21; AR, ALR2), and sorbitol dehydrogenase (EC 1.1.1.14; SDH, SORD) have been widely investigated as the enzymes crucially involved in the pathogenesis of several chronic ... -
Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2021)Glutathione S-transferases (EC 2.5.1.18, GSTs), consisting of at least seven subfamilies, such as alpha, kappa, mu, pi, theta, zeta, and omega, are the family of cytosolic proteins with many known functions and also are ... -
Mannich reaction derived novel boron complexes with amine-bis(phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies
Kılıç, Ahmet; Beyazsakal, Levent; Işık, Mesut; Türkeş, Cüneyt; Necip, Adem; Takım, Kasım; Beydemir, Şükrü (Elsevier, 2020)The amine-bis(phenolate) ligands was prepared through a Mannich reaction utilizing two equivalents of 2,4-di-tert-butylphenol or 4-tert-butylphenol, two equivalents of formaldehyde and a single equivalent of 2-aminoethyl ...
