Browsing by Author "Korkmaz, Işıl Nihan"

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Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors

Korkmaz, Işıl Nihan; Türkeş, Cüneyt; Demir, Yeliz; Öztekin, Aykut; Özdemir, Hasan; Beydemir, Şükrü (Wiley, 2022)

Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium-dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates, esters, and organophosphates. In the current study, we ...
Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies

Korkmaz, Işıl Nihan; Türkeş, Cüneyt; Demir, Yeliz; Özdemir, Hasan; Beydemir, Şükrü (Wiley, 2022)

Paraoxonase 1 (PON1) can metabolize some compounds such as aromatic carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide drugs, some carbamate insecticide classes, nerve gases, and ...