Browsing by Author "Türkeş, Cüneyt"

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Benzenesulfonamide derivatives as potent acetylcholinesterase, alpha-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies

Taslimi, Parham; Işık, Mesut; Türkan, Fikret; Durgun, Mustafa; Türkeş, Cüneyt; Gülçin, İlhami; Beydemir, Şükrü (Taylor & Francis, 2020)

Sulfonamide derivatives exhibit a wide biological activity and can function as potential medical molecules in the development of a drug. Studies have reported that the compounds have an effect on many enzymes. In this ...
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase

Yapar, Gönül; Duran, Hatice Esra; Lolak, Nebih; Akocak, Süleyman; Türkeş, Cüneyt; Durgun, Mustafa; Işık, Mesut; Beydemir, Şükrü (Academic Press-Elsevier Science, 2021)

Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to prevent diabetic complications. In the present study, ...
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors

Korkmaz, Işıl Nihan; Türkeş, Cüneyt; Demir, Yeliz; Öztekin, Aykut; Özdemir, Hasan; Beydemir, Şükrü (Wiley, 2022)

Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium-dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates, esters, and organophosphates. In the current study, we ...
Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies

Türkeş, Cüneyt; Öztürk, Kesebir; Demir, Yeliz; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2021)

Recently, as a drug target in cancer treatment, the superfamily of glutathione S-transferase (GSTs, EC 2.5.1.18) have been invited considerable interest by scientists. In particular, as they are overexpressed in many human ...
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

Güleç, Özcan; Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Yeni, Yeşim; Hacımüftüoğlu, Ahmet; Ereminsoy, Ergün; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Springer, 2022)

The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity antiepileptic, anticancer, antiinfective, antiglaucoma, ...
Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors

Osmaniye, Derya; Türkeş, Cüneyt; Demir, Yeliz; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Beydemir, Şükrü (Wiley, 2022)

Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory ...
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors

Aşkın, Sercan; Tahtacı, Hakan; Türkeş, Cüneyt; Demir, Yeliz; Ece, Abdulilah; Çiftçi, Gülşen Akalın; Beydemir, Şükrü (Academic Press-Elsevier Science, 2021)

Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ...
Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif

Demir, Yeliz; Türkeş, Cüneyt; Çavuş, Muhammet Serdar; Erdoğan, Musa; Muğlu, Halit; Yakan, Hasan; Beydemir, Şükrü (Wiley, 2023)

New Schiff base‐bearing thiosemicarbazones (1–13) were obtained from 4‐hydroxy‐3, 5‐dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail. Density functional ...
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase

Kakakhan, Chnar; Türkeş, Cüneyt; Güleç, Özcan; Demir, Yeliz; Arslan, Mustafa; Özkemahlı, Gizem; Beydemir, Şükrü (Pergamon-Elsevier Science, 2023)

A novel series of 1,2,3-triazole benzenesulfonamide substituted 1,3-dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was designed using a tail approach. The design method relies on the ...
Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors

Türkeş, Cüneyt; Demir, Yeliz; Biçer, Abdullah; Cin, Günseli Turgut; Gültekin, Mehmet Serdar; Beydemir, Şükrü (Wiley, 2023)

Aldose reductase (AR, ALR2; EC 1.1.1.21), an enzyme that converts glucose to fructose on the polyol pathway, is an important member of the Aldo-keto reductase superfamily. ALR2 is part of the rate-limiting step, which is ...
In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors

Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2022)

Polyol pathway enzymes, aldose reductase (EC 1.1.1.21; AR, ALR2), and sorbitol dehydrogenase (EC 1.1.1.14; SDH, SORD) have been widely investigated as the enzymes crucially involved in the pathogenesis of several chronic ...
Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study

Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Wiley, 2021)

Glutathione S-transferases (EC 2.5.1.18, GSTs), consisting of at least seven subfamilies, such as alpha, kappa, mu, pi, theta, zeta, and omega, are the family of cytosolic proteins with many known functions and also are ...
Mannich reaction derived novel boron complexes with amine-bis(phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies

Kılıç, Ahmet; Beyazsakal, Levent; Işık, Mesut; Türkeş, Cüneyt; Necip, Adem; Takım, Kasım; Beydemir, Şükrü (Elsevier, 2020)

The amine-bis(phenolate) ligands was prepared through a Mannich reaction utilizing two equivalents of 2,4-di-tert-butylphenol or 4-tert-butylphenol, two equivalents of formaldehyde and a single equivalent of 2-aminoethyl ...
Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies

Korkmaz, Işıl Nihan; Türkeş, Cüneyt; Demir, Yeliz; Özdemir, Hasan; Beydemir, Şükrü (Wiley, 2022)

Paraoxonase 1 (PON1) can metabolize some compounds such as aromatic carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide drugs, some carbamate insecticide classes, nerve gases, and ...
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

Demir, Yeliz; Ceylan, Hamid; Türkeş, Cüneyt; Beydemir, Şükrü (Taylor & Francis, 2022)

Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and ...
Molecular Docking Studies and the Effect of Fluorophenylthiourea Derivatives on Glutathione-Dependent Enzymes

Demir, Yeliz; Türkeş, Cüneyt; Küfrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2023)

Cancer is a serious problem affecting the health of all human societies. Chemotherapy refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades, researchers have studied about proteins ...
N-substituted phthalazine sulfonamide derivatives as non-classical aldose reductase inhibitors

Türkeş, Cüneyt; Arslan, Mustafa; Demir, Yeliz; Cocaj, Liridon; Nixha, Arleta Rifati; Beydemir, Şükrü (Wiley, 2022)

Aldose reductase (AR, AKR1B1; EC 1.1.1.21) is an aldo-keto reductase that has been widely investigated as an enzyme crucially involved in the pathogenesis of several chronic complications, including nephropathy, neuropathy, ...
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

Sever, Belgin; Altıntop, Mehlika Dilek; Demir, Yeliz; Türkeş, Cüneyt; Özbaş, Kaan; Çiftçi, Gülşen Akalın; Beydemir, Şükrü; Özdemir, Ahmet (De Gruyter, 2021)

In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones (1–8), which were prepared by the solvent-free reaction of 2,4- thiazolidinedione with aromatic aldehydes in the ...
A new series of hydrazones as small-molecule aldose reductase inhibitors

Demir, Yeliz; Türkeş, Cüneyt; Öztürk, Remzi B.; Cantürk, Zerrin; Beydemir, Şükrü; Özdemir, Ahmet (Wiley, 2023)

In the search for small-molecule aldose reductase (AR) inhibitors, new tetrazole-hydrazone hybrids (1-15) were designed. An efficient procedure was employed for the synthesis of compounds 1-15. All hydrazones were subjected ...
Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors

Tokalı, Feyzi Sinan; Demir, Yeliz; Türkeş, Cüneyt; Dinçer, Büşra; Beydemir, Şükrü (Wiley, 2023)

Aldose reductase (AR) is a crucial enzyme of the polyol pathway through whichglucose is metabolized under conditions of hyperglycemia related to diabetes. Aseries of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ...

Browsing by Author "Türkeş, Cüneyt"

Benzenesulfonamide derivatives as potent acetylcholinesterase, alpha-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies ﻿

Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase ﻿

Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors ﻿

Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies ﻿

Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif ﻿

Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors ﻿

Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors ﻿

Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif ﻿

Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase ﻿

Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors ﻿

In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors ﻿

Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study ﻿

Mannich reaction derived novel boron complexes with amine-bis(phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies ﻿

Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies ﻿

Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes ﻿

Molecular Docking Studies and the Effect of Fluorophenylthiourea Derivatives on Glutathione-Dependent Enzymes ﻿

N-substituted phthalazine sulfonamide derivatives as non-classical aldose reductase inhibitors ﻿

A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity ﻿

A new series of hydrazones as small-molecule aldose reductase inhibitors ﻿

Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors ﻿

Benzenesulfonamide derivatives as potent acetylcholinesterase, alpha-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies

Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase

Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors

Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies

Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

Design, synthesis, and biological activity of novel dithiocarbamate-methylsulfonyl hybrids as carbonic anhydrase inhibitors

Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors

Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif

Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase

Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors

In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors

Infection Medications: Assessment In-Vitro Glutathione S-Transferase Inhibition and Molecular Docking Study

Mannich reaction derived novel boron complexes with amine-bis(phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies

Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies

Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

Molecular Docking Studies and the Effect of Fluorophenylthiourea Derivatives on Glutathione-Dependent Enzymes

N-substituted phthalazine sulfonamide derivatives as non-classical aldose reductase inhibitors

A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

A new series of hydrazones as small-molecule aldose reductase inhibitors

Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors