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dc.contributor.authorŞahin, Samet
dc.contributor.authorÇağlayan, Mustafa Oğuzhan
dc.contributor.authorÜstündağ, Zafer
dc.date.accessioned2021-12-07T07:38:12Z
dc.date.available2021-12-07T07:38:12Z
dc.date.issued2020en_US
dc.identifier.citationŞahin, S., Caglayan, M.O. and Üstündağ, Z., 2020. Recent advances in aptamer-based sensors for breast cancer diagnosis: special cases for nanomaterial-based VEGF, HER2, and MUC1 aptasensors. Microchimica Acta, 187(10), pp.1-27.en_US
dc.identifier.issn0026- 3672
dc.identifier.issn1436-5073
dc.identifier.urihttps://doi.org/10.1007/s00604-020-04526-x
dc.identifier.urihttps://hdl.handle.net/11552/2203
dc.description.abstractCancer is one of the most common and important diseases with a high mortality rate. Breast cancer is among the three most common types of cancer in women, and the mortality rate has reached 0.024% in some countries. For early-stage preclinical diagnosis of breast cancer, sensitive and reliable tools are needed. Today, there are many types of biomarkers that have been identified for cancer diagnosis. A wide variety of detection strategies have also been developed for the detection of these biomarkers from serum or other body fluids at physiological concentrations. Aptamers are single-stranded DNA or RNA oligonucleotides and promising in the production of more sensitive and reliable biosensor platforms in combination with a wide range of nanomaterials. Conformational changes triggered by the target analyte have been successfully applied in fluorometric, colorimetric, plasmonic, and electrochemical-based detection strategies. This review article presents aptasensor approaches used in the detection of vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER2), and mucin-1 glycoprotein (MUC1) biomarkers, which are frequently studied in the diagnosis of breast cancer. The focus of this review article is on developments of the last decade for detecting these biomarkers using various sensitivity enhancement techniques and nanomaterials.en_US
dc.language.isoengen_US
dc.publisherSpringer Linken_US
dc.identifier.doi10.1007/s00604-020-04526-xen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectAptasensoren_US
dc.subjectBiosensoren_US
dc.subjectCancer Biomarkeren_US
dc.subjectVEGFen_US
dc.subjectMUC1en_US
dc.subjectHER2en_US
dc.titleRecent advances in aptamer-based sensors for breast cancer diagnosis: special cases for nanomaterial-based VEGF, HER2, and MUC1 aptasensorsen_US
dc.typearticleen_US
dc.relation.ispartofMicrochimica Actaen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümüen_US
dc.authorid0000-0002-0568-4283en_US
dc.authorid0000-0002-7265-1094en_US
dc.authorid0000-0002-5550-106Xen_US
dc.identifier.volume187en_US
dc.identifier.issue10en_US
dc.identifier.startpage1en_US
dc.identifier.endpage27en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.indexPubMeden_US
dc.relation.indexScopusen_US
dc.relation.indexWoSen_US
dc.relation.indexWoS - Science Citation Index Expandeden_US
dc.contributor.institutionauthorŞahin, Samet
dc.contributor.institutionauthorÇağlayan, Mustafa Oğuzhan
dc.description.wospublicationidWOS:000569789300006en_US
dc.description.pubmedpublicationidPMID: 32888061en_US
dc.description.wosqualityQ1en_US


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