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Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
(Elsevier, 2021)
Aldose reductase (AR) acts as a multi-disease target for the design and development of therapeutic agents for the management of diabetic complications as well as non-diabetic diseases. In the search for potent AR inhibitors, ...
An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives
(Elsevier, 2021)
Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven ...
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
(Academic Press-Elsevier Science, 2020)
Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in the polyol pathway, which plays an important role in the development of diabetic complications including cataract, retinopathy, ...
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α-glycosidase and molecular docking studies.
(Wiley, 2020)
Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. alpha-Glycosidase breaks down starch and disaccharides to glucose. Hence, ...
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors
(Wiley, 2021)
A series of novel sulfonates containing quinazolin-4(3H)-one ring derivatives was designed to inhibit aldose reductase (ALR2, EC 1.1.1.21). Novel quinazolinone derivatives (1-21) were synthesized from the reaction of ...
Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
(Wiley, 2023)
Aldose reductase (AR) is a crucial enzyme of the polyol pathway through whichglucose is metabolized under conditions of hyperglycemia related to diabetes. Aseries of novel acetic acid derivatives containing quinazolin‐4(3H)‐one ...
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo- pyridazinone moiety
(Elsevier, 2022)
The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol and then
converted to fructose. The first and rate limiting enzyme of this pathway, aldose reductase (ALR2),
is a drug target for ...
A new series of hydrazones as small-molecule aldose reductase inhibitors
(Wiley, 2023)
In the search for small-molecule aldose reductase (AR) inhibitors, new tetrazole-hydrazone hybrids (1-15) were designed. An efficient procedure was employed for the synthesis of compounds 1-15. All hydrazones were subjected ...
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
(De Gruyter, 2021)
In an effort to identify potent aldose reductase
(AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones (1–8),
which were prepared by the solvent-free reaction of 2,4-
thiazolidinedione with aromatic aldehydes in the ...
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
(Academic Press-Elsevier Science, 2021)
Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes the formation of sorbitol from
glucose in the polyol pathway. ALR2 inhibition is required to prevent diabetic complications. In the present
study, ...
