Platelet activation in ocular Behcet's patients with posterior segment involvement

Abstract

PURPOSE: The aim of the present study was to assess platelet activation by analyzing three platelet activation parameters in ocular Behcet's disease (BD): mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). METHODS: Twenty-nine patients with active ocular BD (Group 1), 40 patients with inactive ocular BD (Group 2), and 40 healthy adult individuals serving as controls (Group 3) were evaluated. All of the individuals had been performed the complete ophthalmologic evaluation. The levels of MPV, PDW, and PCT were measured in each group. RESULTS: The mean MPV level was +/- 0.97 in Group 1, 8.32 +/- 1.04 in Group 2, and 7.77 +/- 0.72 in Group 3. The mean PDW level was 15.12 +/- 1.09 in Group 1, 14.97 +/- 1.02 in Group 2, and 14.52 +/- 0.82 in Group 3. The mean PCT level was 0.23 +/- 0.07 in Group 1, 0.21 +/- 0.04 in Group 2, and 0.18 +/- 0.03 in Group 3. MPV, PDW, and PCT levels were significantly higher in ocular BD patients than controls (P < 0.05). CONCLUSION: Platelet activation may affect vascular occlusion in ocular Behcet's patients with posterior segment involvement. This result may be important in evaluating ocular BD patients.