Nanodelivery of herbal and phyto-antioxidants

Abstract

Phyto-bioactive compounds such as curcumin, resveratrol, catechins, and quercetin are among the most widely used natural compounds used as potential modulators of free radical-induced cellular damage. However, the therapeutic potential of these compounds is limited by their low bioavailability associated with poor solubility, stability, and absorbance in the gastrointestinal tract. Recently, new nanotechnology-based systems have been developed for the therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems provide many benefits in preclinical research over conventional preparations, including superior solubility and stability, extended half-life, improved epithelial permeability and bioavailability, increased tissue targeting, and minimized side effects. © 2022 John Wiley & Sons, Inc. All rights reserved.