A sensitive spectrophotometric ellipsometry based Aptasensor for the vascular endothelial growth factor detection

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dc.authoridUstundag, Zafer/0000-0002-5550-106X
dc.contributor.authorKariper, Ishak Afsin
dc.contributor.authorUstundag, Zafer
dc.contributor.authorCaglayan, Mustafa Oguzhan
dc.date.accessioned2025-05-20T18:57:56Z
dc.date.issued2021
dc.departmentBilecik Şeyh Edebali Üniversitesi
dc.description.abstractA sensitive and selective, aptamer and spectroscopic ellipsometry based sensor is reported here for the early diagnosis of breast cancer, which is a common type of cancer following lung cancer. It was aimed to develop a single-step and label-free assay for the sensitive and selective detection of VEGF165. To this end, two different aptamers and spectroscopic ellipsometry were used. In the presented study, by determining the appropriate aptamer immobilization conditions, the spectroscopic ellipsometry technique was successfully applied for the detection of VEGF165 at the range of 1 pM-1000 pM in the buffer. Aptasensors have a detection limit of 5.81 pM and 4.29 pM, respectively.
dc.description.sponsorshipScientific Research Projects Division of Bilecik Seyh Edebali University (BSEU-BAP, Bilecik, Turkey) [2019-01.BSEU.03-03]
dc.description.sponsorshipThis study has been done between June 2019 and April 2020. The authors thank the Scientific Research Projects Division of Bilecik Seyh Edebali University (BSEU-BAP, Bilecik, Turkey) for their supports and valuable grants under project number 2019-01.BSEU.03-03.
dc.identifier.doi10.1016/j.talanta.2020.121982
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.pmid33592730
dc.identifier.scopus2-s2.0-85098461495
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2020.121982
dc.identifier.urihttps://hdl.handle.net/11552/8000
dc.identifier.volume225
dc.identifier.wosWOS:000652032600049
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWoS
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWoS - Science Citation Index Expanded
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250518
dc.subjectAptamers
dc.subjectBiosensors
dc.subjectBreast cancer
dc.subjectSpectroscopic ellipsometry
dc.subjectVEGF
dc.titleA sensitive spectrophotometric ellipsometry based Aptasensor for the vascular endothelial growth factor detection
dc.typeArticle

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