Determination of COL1A1 rs1800012 Polymorphism Related to Ligament and Tendon Injury in Turkish Professional Bodybuilders: Experimental Research

Abstract

Objective: Athletic performance is affected by genetic and environmental factors. Bodybuilding has been increasing around the world in recent years and it is accepted that the factors affecting athletic performance are the most important influences to achieve suc- cess in bodybuilding. The aim of our study is to determine the distri- bution of COL1A1 rs1800012 polymorphism associated with ligament and tendon injuries due to muscle tears with weight training and to com- pare the results with sedentary individuals.Material and Methods: A total of 15 Turkish bodybuilders and 50 sedentary individuals as a con- trol group participated in our study. DNA isolation from peripheral blood samples of athletes was performed using a commercial kit (In- vitrogen, Van Allen Way Carlsbad, Calif., USA). Genotyping was done by real-time polymerase chain reaction. Results: GG genotype and G allele were higher in both bodybuilders and control groups. In addition, there was no statistically significant difference in terms of genotype and allelic frequency of the COL1A1 rs1800012 polymorphism be- tween the bodybuilders and the control group. Conclusion: Our study is the first to examine the COL1A1 rs1800012 polymorphism in Turk- ish bodybuilders. Our results report that the TT genotype and T allele may be protective against ligament and tendon injuries, similar to the literature. We think that similar studies will guide future studies in terms of sports injuries and COL1A1 rs1800012 polymorphism.