WHICH POLYMORPHISM IS THE DISTINGUISHING FACTOR FOR FITNESS ATHLETES: THE ACE INDEL OR ACTN3 RS1815739?

Abstract

Purpose: The purpose of this research was to investigate the occurrence of ACE InDel and ACTN3 rs1815739 in sub -elite fitness athletes and to determine which gene is distinctive by comparing genotype and allele frequencies with sedentary individuals. Material and Methods: Forty-one sub -elite fitness athletes and the same number of the sedentary volunteers participated in the study. Genetic analyzes of the athletes were determined using molecular-based methods such as DNA isolation from peripheral blood samples by using a commercial kit and genotyping with real -time polymerase chain reaction (Real -Time PCR), and conventional polymerase chain reaction (PCR). The Chi-Square test was used to compare the genotype distribution and I, D, C, and T allele frequencies of ACE InDel and ACTN3 rs1815739 polymorphisms for statistical significance. Results: No statistical difference was found for ACE I/D polymorphism in terms of both genotype distribution (p=0.4438). A comparison of sub -elite fitness athletes and control groups showed that the ACTN3 rs1815739 polymorphism had a statistically significant difference in terms of genotype distribution (p=0.0313). Conclusion: In conclusion, we suggest that the ACTN3 rs1815739 polymorphism is more effective than the ACE InDel polymorphism in fitness athletes.