Could Magnesium Be Associated with Urinary Incontinence and Overactive Bladder Disease in the General Population?

Abstract

Objective: Calcium (Ca) has been very well known to play a significant role in bladder detrusor contraction and stimulation. Magnesium (Mg), on the other hand, functions as an antagonist of Ca in the detrusor muscle. We designed our research on the question of whether magnesium may be associated with urological diseases such as overactive bladder and urinary incontinence. Material and Method: A total of 124 patients with urinary incontinence and overactive bladder symptoms were randomized. One hundred twenty-two patients for control group who applied to the urology outpatient clinic and internal medicine outpatient clinic of the patients were included in the study. The effective parameters in Mg and bone metabolism, and those that may influence Mg metabolism were measured among the participating patients. Results: Albumin values were statistically significant when compared with the control group (p <0.0001, AUC =0.73). Likewise, ca values were found to be significant between the patient group and the control group according to the ROC analysis (p =0.0016, AUC =0.61). Statistical significance was determined according to ROC analysis for phosphorus and parathormone and vitamin D (P value and AUC respectively p <0.0001, AUC=0.65 and p <0.0001, AUC =0.86, p =0.0007, AUC =0.62). Conclusion: According our cross sectional study magnesium level not statistically significiant. Since urinary incontinence and overactive bladder disease require chronic drug use, treatments provide symptomatic relief but do not cure. We believe that studies with more substantial patient participation are required to develop curative treatment and to fully understand the pathophysiology of these diseases.