Genetic Hints of Celiac Disease Current Researches

Abstract

Celiac disease is an autoimmune disease that is characterized corruption of small bowel’s absorption due to food intolerance against gluten protein in cereals as wheat, rye, oats and barley and can be seen at any age. One in every hundred individuals throughout Turkey and world is celiac patient. Immunologic peptides in gluten protein received via foods trigger activation of T lymphocytes and stimulation of inflammatory mechanisms together immune response. T lymphocytes activated by gluten cause inflammation in small bowel and corruption of absorption. Many genetic and molecular studies for achieving clues to the treatment of celiac disease have been performed. These studies have been focused on genes, metabolic pathways and molecules which have been proposed to be related with celiac disease. Main studies are on genotyping of HLA molecules interrelated with the disease and polymorphism research. In addition there are studies on biomarkers for diagnosis and gene expressions. We reviewed recent data that hints genetic clues of celiac disease.