PARP1 (poly(ADP-ribose) polymerase 1)
| dc.contributor.author | Tunçer, Sinem | |
| dc.contributor.author | Kavak, Kubra | |
| dc.date.accessioned | 2025-05-20T18:47:46Z | |
| dc.date.issued | 2020 | |
| dc.department | Bilecik Şeyh Edebali Üniversitesi | |
| dc.description.abstract | PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. Particularly, due to its decisive role in several DNA repair pathways, the inhibition of PARP1 has emerged as a prominent therapeutic option in cancer treatment, by improving the efficiency of chemotherapeutics or radiation therapy. © 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology. | |
| dc.identifier.doi | 10.4267/2042/70775 | |
| dc.identifier.endpage | 312 | |
| dc.identifier.issn | 1768-3262 | |
| dc.identifier.issue | 8 | |
| dc.identifier.scopus | 2-s2.0-85086871364 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 300 | |
| dc.identifier.uri | https://doi.org/10.4267/2042/70775 | |
| dc.identifier.uri | https://hdl.handle.net/11552/6618 | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Atlas of genetics and cytogenetics in oncology and haematology | |
| dc.relation.ispartof | Atlas of Genetics and Cytogenetics in Oncology and Haematology | |
| dc.relation.publicationcategory | Diğer | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_Scopus_20250518 | |
| dc.subject | Cancer | |
| dc.subject | DNA repair | |
| dc.subject | Inflammation | |
| dc.subject | Neurodegenerative diseases | |
| dc.subject | PARylation | |
| dc.subject | Viral infections | |
| dc.title | PARP1 (poly(ADP-ribose) polymerase 1) | |
| dc.type | Review |
